Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 1/20 | 0.50 |
| ▸ | CTSS | P25774 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.41 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497837 | 0.86 | CTSL (0.49) | CTSLCTSBCTSSALDH1A1HPGD | |
| SCHEMBL3424499 | 0.78 | CTSL (0.61) | CTSLCTSBCTSSALDH1A1HPGD | |
| SCHEMBL3428350 | 0.73 | CTSL (0.62) | CTSLCTSBCTSSALDH1A1HPGD | |
| SCHEMBL2566744 | 0.73 | RAB9A (0.55) | CTSLCTSBCTSSALDH1A1USP2 | |
| SCHEMBL13753379 | 0.72 | ALDH1A1 (0.63) | ALDH1A1HPGDUSP2MAPK1HSD17B10 | |
| SCHEMBL2572218 | 0.71 | POLB (0.44) | ALDH1A1HPGDMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL2569570 | 0.71 | HTT (0.45) | CTSLCTSBCTSSALDH1A1HPGD | |
| SCHEMBL2567760 | 0.69 | POLB (0.43) | ALDH1A1HPGDMAPK1SMN1; SMN2NPSR1 | |
| SCHEMBL26970100 | 0.68 | NPSR1 (0.58) | ALDH1A1HPGDUSP2MAPK1HSD17B10 | |
| SCHEMBL2566849 | 0.68 | SMN1; SMN2 (0.41) | ALDH1A1HPGDMAPK1SMN1; SMN2NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1747217-A1 | NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | Boehringer Ingelheim International GmbH (DE) | 2007-01-31 | — | — | EP | disclosed |
| WO-2005111029-A1 | NOVEL SUBSTITUTED THIOPHENECARBOXAMIDES, THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2005-11-24 | — | — | WO | disclosed |