Albendazole

Albendazole

SCHEMBL5502364

CCCSc1ccc2nc(NC(=O)OC)[nH]c2c1.O=S(=O)(O)O

nearest known ligand 0.91

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3CALCRLCHRM1CHRM2CHRM3F2RMAOAMAOBMAP2K1MAP2K2NTRK1NTRK2NTRK3OPRD1OPRK1OPRM1P2RY12PKLRSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASLC18A2SLC6A2SLC6A3TLR7TLR9TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8dacAdacBdacCfolAftsImrcAmrcBmrdApolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmB1rpmB2rpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmHrpmIrpmJrpmJ2rpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsR1rpsR2rpsSrpsTrpsUrpsZykgMykgO

The experimentally established mechanism targets of Albendazole. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TUBB4A known ✓ P04350 6/20 0.58
TUBB known ✓ P07437 6/20 0.58
TUBA3C known ✓ P0DPH7 6/20 0.58
TUBA1B known ✓ P68363 6/20 0.58
TUBA4A known ✓ P68366 6/20 0.58
TUBB4B known ✓ P68371 6/20 0.58
TUBB3 known ✓ Q13509 6/20 0.58
TUBB2A known ✓ Q13885 6/20 0.58
TUBB8 known ✓ Q3ZCM7 6/20 0.58
TUBA3E known ✓ Q6PEY2 6/20 0.58
TUBA1A known ✓ Q71U36 6/20 0.58
TUBA1C known ✓ Q9BQE3 6/20 0.58
TUBB6 known ✓ Q9BUF5 6/20 0.58
TUBB2B known ✓ Q9BVA1 6/20 0.58
TUBB1 known ✓ Q9H4B7 6/20 0.58
MAOA known ✓ P21397 1/20 0.47
SLC6A3 known ✓ Q01959 1/20 0.47
LMNA P02545 8/20 0.91
CYP1A2 P05177 6/20 0.91
MAPK1 P28482 4/20 0.91

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Albendazole SCHEMBL31704207 0.96 LMNA (1.00) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL247151 0.96 LMNA (1.00) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL29612190 0.88 LMNA (0.85) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL28470926 0.87 LMNA (0.73) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
SCHEMBL7258034 0.87 LMNA (0.83) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL7969988 0.86 LMNA (0.83) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL29409236 0.86 LMNA (0.83) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL44682 0.86 LMNA (0.83) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL23038783 0.86 LMNA (0.74) LMNACYP1A2MAPK1SMN1; SMN2NPSR1
Albendazole SCHEMBL28582887 0.85 LMNA (0.81) LMNACYP1A2MAPK1SMN1; SMN2NPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1379242-A4 METHOD FOR TREATMENT OF CANCER AND COMPOSITIONS FOR USE THEREIN NEWSOUTH INNOVATIONS PTY LTD (AU) 2007-10-03 EP disclosed
EP-1379242-A1 METHOD FOR TREATMENT OF CANCER AND COMPOSITIONS FOR USE THEREIN UNISEARCH LIMITED (AU) 2004-01-14 EP disclosed
WO-2002076454-A1 METHOD FOR TREATMENT OF CANCER AND COMPOSITIONS FOR USE THEREIN UNISEARCH LIMITED (AU) 2002-10-03 WO disclosed