Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | LDHA | P00338 | 1/20 | 0.31 |
| ▸ | LDHB | P07195 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5505492 | 0.99 | PDCD1LG2 (0.31) | PDCD1LG2CD274LDHALDHB | |
| SCHEMBL5504883 | 0.89 | CYP11B2 (0.35) | PDCD1LG2CD274LDHACNR2 | |
| SCHEMBL5506971 | 0.88 | CNR2 (0.32) | PDCD1LG2CD274CNR2 | |
| Hydrochloric Acid SCHEMBL5503796 | 0.88 | CYP11B2 (0.34) | PDCD1LG2CD274LDHACNR2 | |
| SCHEMBL5501423 | 0.85 | HTR6 (0.34) | — | |
| Hydrochloric Acid SCHEMBL5506619 | 0.84 | HTR6 (0.33) | — | |
| SCHEMBL5504207 | 0.83 | MEN1 (0.33) | PDCD1LG2CD274 | |
| SCHEMBL5503412 | 0.82 | PDCD1LG2 (0.33) | PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5504025 | 0.82 | PDCD1LG2 (0.33) | PDCD1LG2CD274 | |
| SCHEMBL5503074 | 0.81 | DPP4 (0.32) | PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |