Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 7/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 7/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.39 |
| ▸ | RORC | P51449 | 2/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL352862 | 0.90 | RORC (0.47) | NR1H2NR1H3MEN1KMT2AKIF11 | |
| SCHEMBL6302951 | 0.82 | CNR2 (0.47) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| SCHEMBL11152193 | 0.82 | ALDH1A1 (0.51) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| SCHEMBL15894604 | 0.81 | ALDH1A1 (0.55) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| Hydrochloric Acid SCHEMBL9660363 | 0.80 | ALDH1A1 (0.50) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| SCHEMBL242391 | 0.80 | KMT2A (0.46) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| SCHEMBL352863 | 0.80 | KIF11 (0.39) | NR1H2KIF11HDAC8MCHR1LMNA | |
| SCHEMBL11328593 | 0.79 | ALDH1A1 (0.59) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| SCHEMBL5523437 | 0.79 | KMT2A (0.45) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD | |
| SCHEMBL30848429 | 0.79 | KMT2A (0.45) | MEN1ALDH1A1HSP90AA1CYP2C9HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828111-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | Neurochem (International) Limited (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006059252-A2 | METHODS AND FLUORINATED COMPOSITIONS FOR TREATING AMYLOID-RELATED DISEASES | NEUROCHEM (INTERNATIONAL) LIMITED (CH) | 2006-06-08 | — | — | WO | disclosed |