Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 7/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5500515 | 0.89 | P2RX7 (0.42) | KMT2ASMN1; SMN2P2RX7LMNA | |
| SCHEMBL5500083 | 0.83 | HCRTR1 (0.33) | P2RX7 | |
| Hydrochloric Acid SCHEMBL5505760 | 0.82 | HCRTR1 (0.33) | — | |
| SCHEMBL5509665 | 0.80 | CYP11B1 (0.38) | — | |
| SCHEMBL5500075 | 0.77 | PDCD1LG2 (0.35) | KMT2AL3MBTL1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5500736 | 0.77 | KMT2A (0.35) | KMT2AL3MBTL1SMN1; SMN2P2RX7HPGD | |
| SCHEMBL5500067 | 0.77 | KMT2A (0.36) | KMT2AL3MBTL1SMN1; SMN2P2RX7 | |
| SCHEMBL5500662 | 0.76 | F10 (0.33) | KMT2AALDH1A1 | |
| SCHEMBL5500660 | 0.76 | F10 (0.33) | KMT2AALDH1A1 | |
| SCHEMBL5501290 | 0.76 | KMT2A (0.43) | KMT2ASMN1; SMN2P2RX7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | disclosed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | disclosed |