Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 3/20 | 0.42 |
| ▸ | JAK1 | P23458 | 3/20 | 0.42 |
| ▸ | GRM5 | P41594 | 2/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | DTYMK | P23919 | 1/20 | 0.39 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | VNN1 | O95497 | 1/20 | 0.38 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.37 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25262300 | 0.82 | GPR119 (0.49) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL24392453 | 0.82 | TACR1 (0.47) | GPR119OPRD1OPRK1RORC | |
| SCHEMBL3325436 | 0.81 | GPR119 (0.50) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL25299744 | 0.80 | GPR119 (0.50) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL3886498 | 0.78 | GPR119 (0.46) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL29535693 | 0.78 | GPR119 (0.51) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL13059786 | 0.78 | GPR119 (0.51) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL3885199 | 0.78 | GPR119 (0.46) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL5472801 | 0.78 | GPR119 (0.51) | GPR119POLBOPRD1OPRK1JAK2 | |
| SCHEMBL20493552 | 0.76 | OPRD1 (0.52) | GPR119POLBOPRD1OPRK1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745018-A1 | AZETIDINE GLYCINE TRANSPORTER INHIBITORS | Merck & Co., Inc. (US) | 2007-01-24 | — | — | EP | disclosed |
| WO-2005110983-A1 | AZETIDINE GLYCINE TRANSPORTER INHIBITORS | MERCK & CO., INC. (US) | 2005-11-24 | — | — | WO | disclosed |