Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 7/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CASP1 | P29466 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 1/20 | 0.31 |
| ▸ | DRD4 | P21917 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | HTR2B | P41595 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5501923 | 0.86 | DRD2 (0.39) | DRD2HTR2AHTR1ADRD4DRD3 | |
| SCHEMBL2784104 | 0.80 | MAPT (0.41) | DRD2HTR2AHRH1KDM4EALDH1A1 | |
| SCHEMBL2783446 | 0.80 | DRD2 (0.43) | DRD2HTR2AHRH1HTR1AHTR7 | |
| SCHEMBL5514024 | 0.77 | DRD2 (0.34) | DRD2HTR1AHTR7DRD3 | |
| SCHEMBL5499969 | 0.75 | HTR1A (0.36) | DRD2HTR2AHTR1AHTR7DRD3 | |
| SCHEMBL5505305 | 0.74 | DRD2 (0.37) | DRD2HTR2AHRH1HTR1AKDM4E | |
| SCHEMBL2784966 | 0.73 | DRD2 (0.43) | DRD2HTR2AHRH1HTR1AKDM4E | |
| SCHEMBL2783669 | 0.72 | DRD2 (0.44) | DRD2HTR2AHRH1KDM4EALDH1A1 | |
| SCHEMBL2783260 | 0.70 | DRD2 (0.52) | DRD2HTR1ADRD3 | |
| SCHEMBL2784464 | 0.70 | DRD2 (0.52) | DRD2HTR2AHRH1HTR1AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |