Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.39 |
| ▸ | DRD3 | P35462 | 7/20 | 0.39 |
| ▸ | DRD4 | P21917 | 4/20 | 0.35 |
| ▸ | HTR2A | P28223 | 3/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504155 | 0.86 | DRD2 (0.35) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL2784104 | 0.79 | MAPT (0.41) | DRD2DRD3DRD4HTR2A | |
| SCHEMBL2783260 | 0.77 | DRD2 (0.52) | DRD2DRD3HTR1AHTR6 | |
| SCHEMBL5510683 | 0.73 | DRD2 (0.43) | DRD2DRD3HTR1AHTR6 | |
| SCHEMBL2783023 | 0.72 | DRD2 (0.44) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL5514024 | 0.71 | DRD2 (0.34) | DRD2DRD3HTR1AHTR6 | |
| SCHEMBL2783669 | 0.71 | DRD2 (0.44) | DRD2DRD3DRD4HTR2AHTR6 | |
| SCHEMBL5502634 | 0.71 | DRD2 (0.45) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL5525414 | 0.70 | DRD2 (0.39) | DRD2DRD3DRD4HTR2AHTR1A | |
| SCHEMBL5503076 | 0.70 | DRD2 (0.38) | DRD2DRD3DRD4HTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | claimed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | claimed |