Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.37 |
| ▸ | TNF | P01375 | 1/20 | 0.36 |
| ▸ | LITAF | Q99732 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 4/20 | 0.34 |
| ▸ | HTR2B | P41595 | 3/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.34 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | DPP4 | P27487 | 2/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.33 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | HTR2A | P28223 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503363 | 0.86 | MMP13 (0.36) | HCN4HTR2CHTR2BCNR1PDCD1LG2 | |
| SCHEMBL5499711 | 0.80 | DPP4 (0.36) | DPP4DPP8DPP9F10 | |
| SCHEMBL5504186 | 0.80 | F10 (0.35) | P2RX7DPP4DPP8DPP9F10 | |
| SCHEMBL5503421 | 0.76 | F10 (0.32) | DPP4DPP8DPP9F10 | |
| SCHEMBL5501423 | 0.75 | HTR6 (0.34) | HCRTR1HCRTR2DPP4DPP8DPP9 | |
| SCHEMBL5500707 | 0.75 | F10 (0.33) | DPP4DPP8DPP9F10 | |
| SCHEMBL5502855 | 0.75 | F10 (0.33) | DPP4DPP8DPP9F10 | |
| SCHEMBL5503355 | 0.75 | MEN1 (0.34) | DPP4DPP8DPP9F10 | |
| SCHEMBL5504207 | 0.75 | MEN1 (0.33) | P2RX7HTR2CHTR2BDPP4PDCD1LG2 | |
| Hydrochloric Acid SCHEMBL5506619 | 0.74 | HTR6 (0.33) | HCRTR1HCRTR2DPP4DPP8DPP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |