Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 10/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.41 |
| ▸ | NOS3 | P29474 | 3/20 | 0.39 |
| ▸ | NOS1 | P29475 | 3/20 | 0.39 |
| ▸ | NOS2 | P35228 | 3/20 | 0.39 |
| ▸ | DRD3 | P35462 | 4/20 | 0.36 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505289 | 0.87 | DRD2 (0.42) | DRD2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL2781919 | 0.86 | DRD2 (0.48) | DRD2DRD3DRD4KDM4EMEN1 | |
| SCHEMBL2785380 | 0.85 | DRD2 (0.49) | DRD2DRD3DRD4KDM4EALDH1A1 | |
| SCHEMBL2782347 | 0.85 | DRD2 (0.54) | DRD2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL2780423 | 0.84 | DRD2 (0.56) | DRD2SLC6A4DRD3HTR6HRH3 | |
| SCHEMBL5501921 | 0.83 | ADRA2A (0.41) | DRD2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL3772743 | 0.82 | NOS3 (0.46) | DRD2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL2783316 | 0.81 | DRD4 (0.46) | DRD2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL5503078 | 0.78 | DRD2 (0.34) | DRD2SLC6A4NOS3NOS1NOS2 | |
| SCHEMBL5517963 | 0.78 | DRD2 (0.36) | DRD2SLC6A4NOS3NOS1NOS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |