Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.76 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.62 |
| ▸ | LMNA | P02545 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | NPC1 | O15118 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.53 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14985198 | 0.95 | PTPN1 (0.73) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL3364969 | 0.89 | PTPN1 (0.73) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL22531834 | 0.87 | MAPT (0.69) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL5508682 | 0.87 | PTPN1 (0.67) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL3904837 | 0.87 | PTPN1 (0.67) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL5510635 | 0.85 | ALDH1A1 (0.68) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL5511609 | 0.84 | PTPN1 (0.62) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL5503365 | 0.83 | KMT2A (0.62) | PTPN1PTPN11ALDH1A1HPGDMEN1 | |
| SCHEMBL3897213 | 0.83 | MEN1 (0.72) | PTPN1PTPN11ALDH1A1MEN1KMT2A | |
| SCHEMBL29610955 | 0.82 | PTPN1 (0.71) | PTPN1PTPN11ALDH1A1HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070203117-A1 | modulators of nicotinic and/or of monoamine receptors; as diagnostic tools or monitoring agents; for in vivo neuroimaging in labeled/unlabelled forms; inflammation, pain, neurodegenerative disorders; cholinergic ligands;5-(4-Benzoylamino-phenyl)-furan-2-carboxylic acid(1-aza-bicyclo[2.2.2]oct-3-yl)-amide | NEUROSEARCH A/S (DK) | 2007-08-30 | — | — | US | claimed |
| EP-1751150-A2 | NOVEL AZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2007-02-14 | — | — | EP | claimed |
| WO-2005111033-A2 | NOVEL AZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-11-24 | — | — | WO | claimed |
| US-20070203117-A1 | modulators of nicotinic and/or of monoamine receptors; as diagnostic tools or monitoring agents; for in vivo neuroimaging in labeled/unlabelled forms; inflammation, pain, neurodegenerative disorders; cholinergic ligands;5-(4-Benzoylamino-phenyl)-furan-2-carboxylic acid(1-aza-bicyclo[2.2.2]oct-3-yl)-amide | NEUROSEARCH A/S (DK) | 2007-08-30 | — | — | US | disclosed |
| EP-1751150-A2 | NOVEL AZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2007-02-14 | — | — | EP | disclosed |
| WO-2005111033-A2 | NOVEL AZABICYCLIC ARYL DERIVATIVES | NEUROSEARCH A/S (DK) | 2005-11-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070203117-A1 | modulators of nicotinic and/or of monoamine receptors; as diagnostic tools or monitoring agents; for in vivo neuroimaging in labeled/unlabelled forms; inflammation, pain, neurodegenerative disorders; cholinergic ligands;5-(4-Benzoylamino-phenyl)-furan-2-carboxylic acid(1-aza-bicyclo[2.2.2]oct-3-yl)-amide | CHRNA5, CHRNA2, CHRNA6 | PTPN1 3611/4885PTPN11 3410/4885ALDH1A1 923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.