Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.73 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.72 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.64 |
| ▸ | LMNA | P02545 | 2/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PGR | P06401 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | MAPT | P10636 | 2/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.57 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504372 | 0.89 | PTPN1 (0.76) | PTPN1PTPN11NPC1RAB9AKDM4E | |
| SCHEMBL18085798 | 0.85 | PTPN1 (1.00) | PTPN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL14985198 | 0.84 | PTPN1 (0.73) | PTPN1PTPN11NPC1RAB9AKDM4E | |
| SCHEMBL14160276 | 0.83 | PTPN1 (0.96) | PTPN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL10136221 | 0.83 | PTPN1 (0.96) | PTPN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL3364955 | 0.83 | NPC1 (0.71) | PTPN1PTPN11NPC1RAB9AKDM4E | |
| SCHEMBL126415 | 0.83 | PTPN1 (0.87) | PTPN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL13716704 | 0.82 | PTPN1 (0.67) | PTPN1PTPN11NPC1RAB9AKDM4E | |
| SCHEMBL14715824 | 0.81 | NPC1 (0.88) | PTPN1NPC1RAB9AKDM4EMEN1 | |
| SCHEMBL18103163 | 0.81 | NPC1 (0.88) | PTPN1NPC1RAB9AKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7745456-B2 | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2010-06-29 | — | — | US | disclosed |
| US-20080058372-A1 | Synthesis and antimicrobial activity of novel dicationic ''reversed amidines'' | The University of North Carolina at Chapel Hill: | 2008-03-06 | — | — | US | disclosed |
| US-7241795-B2 | Synthesis and antimicrobial activity of novel dicationic “reversed amidines” | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2007-07-10 | — | — | US | disclosed |
| US-20040235927-A1 | Synthesis and antimicrobial activity of novel dicationic \"reversed amidines\ | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2004-11-25 | — | — | US | disclosed |
| US-6737440-B2 | 2,5-BIS ((ALKYL (OR ARYL) IMINO) AMINOPHENYL) FURANS, THIOPHENES OR PYRROLES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL | 2004-05-18 | — | — | US | disclosed |
| US-6706754-B2 | ANTIPROTOZOA AGENTS, PARASITICIDES | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY | 2004-03-16 | — | — | US | disclosed |
| EP-1337510-A2 | SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC \"REVERSED AMIDINES\ | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2003-08-27 | — | — | EP | disclosed |
| US-20030083362-A1 | Synthesis and antimicrobial activity of novel dicationic\"reversed amidines\ | GEORGIA STATE UNIVERSITY | 2003-05-01 | — | — | US | disclosed |
| US-20020156098-A1 | Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis | ARMY, UNITED STATES | 2002-10-24 | — | — | US | disclosed |
| WO-2002057224-A2 | SYNTHESIS AND ANTIMICROBIAL ACTIVITYOF NOVEL DICATIONIC 'REVERSED AMIDINES' | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2002-07-25 | — | — | WO | disclosed |
| WO-2002036588-A2 | REVERSED AMIDINES AND METHODS OF USING FOR TREATING, PREVENTING, OR INHIBITING LEISHMANIASIS | U.S. ARMY MEDICAL RESEARCH AND MATERIEL COMMAND (US) | 2002-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030083362-A1 | Synthesis and antimicrobial activity of novel dicationic\"reversed amidines\ | HRH4, TLR7, DDAH1 | PTPN1 2896/4885PTPN11 2308/4885NPC1 2269/4885 |
| US-20040235927-A1 | Synthesis and antimicrobial activity of novel dicationic \"reversed amidines\ | HRH4, HDHD5, MRPS7 | PTPN1 3126/4885PTPN11 2575/4885NPC1 1459/4885 |
| US-20080058372-A1 | Synthesis and antimicrobial activity of novel dicationic ''reversed amidines'' | TLR7, DHRS9, TLR8 | PTPN1 2410/4885PTPN11 1558/4885NPC1 3601/4885 |
| US-20020156098-A1 | Reversed amidines and methods of using for treating, preventing, or inhibiting leishmaniasis | ARG1, NAT1, CTSA | PTPN1 2392/4885PTPN11 3289/4885NPC1 203/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.