Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 3/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.40 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.40 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.40 |
| ▸ | NLRP3 | Q96P20 | 3/20 | 0.39 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.33 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SGK1 | O00141 | 1/20 | 0.31 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | HRH2 | P25021 | 1/20 | 0.31 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.31 |
| ▸ | HTR2A | P28223 | 1/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.31 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504392 | 0.89 | MAPT (0.34) | ADORA2AADORA3ADORA1ADORA2BNLRP3 | |
| SCHEMBL4069055 | 0.73 | PRMT5 (0.34) | ADORA2AADORA3ADORA1 | |
| SCHEMBL4068898 | 0.72 | TLR7 (0.34) | TLR7 | |
| SCHEMBL3862404 | 0.71 | TLR8 (0.37) | ADORA2AADORA3ADORA1TLR7TLR8 | |
| SCHEMBL3977482 | 0.71 | TLR7 (0.37) | ADORA2AADORA3ADORA1ADORA2BTLR7 | |
| SCHEMBL5509023 | 0.71 | KDM4E (0.36) | ADORA2AADORA3ADORA1ADORA2BTLR7 | |
| Hydrochloric Acid SCHEMBL9134401 | 0.70 | TLR7 (0.36) | ADORA2ATLR7TLR8KDM4EMAPT | |
| SCHEMBL4586839 | 0.70 | TLR7 (0.38) | ADORA2AADORA3ADORA1ADORA2BTLR7 | |
| SCHEMBL5275496 | 0.69 | TLR7 (0.31) | TLR7KCNH2 | |
| SCHEMBL8322469 | 0.68 | HTT (0.36) | TLR7TLR8POLBSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1851218-A2 | HYDROXYALKYL SUBSTITUTED IMIDAZOQUINOLINE COMPOUNDS AND METHODS | 3M Innovative Properties Company (US) | 2007-11-07 | — | — | EP | disclosed |
| WO-2006091567-A2 | HYDROXYALKYL SUBSTITUTED IMIDAZOQUINOLINE COMPOUNDS AND METHODS | COLEY PHARMACEUTICAL GROUP, INC. (US) | 2006-08-31 | — | — | WO | disclosed |