Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | CTSS | P25774 | 14/20 | 0.40 |
| ▸ | CTSL | P07711 | 2/20 | 0.40 |
| ▸ | CTSK | P43235 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5497674 | 0.78 | CTSS (0.60) | CTSSCTSLCTSK | |
| SCHEMBL6687593 | 0.78 | CTSS (0.60) | CTSSCTSLCTSK | |
| SCHEMBL4468350 | 0.72 | CTSS (0.71) | CTSSCTSLCTSK | |
| SCHEMBL4468345 | 0.72 | CTSS (0.71) | CTSSCTSLCTSK | |
| SCHEMBL5408243 | 0.68 | CTSS (0.53) | CTSSCTSLCTSKDPP9 | |
| SCHEMBL6691416 | 0.68 | CTSS (0.53) | CTSSCTSLCTSKDPP9 | |
| SCHEMBL6690869 | 0.67 | CTSS (0.60) | CTSSCTSLCTSKDPP9 | |
| SCHEMBL3023914 | 0.67 | CTSS (0.65) | CTSSCTSLCTSK | |
| SCHEMBL27636160 | 0.66 | SLC6A2 (0.49) | SLC6A2SLC6A4CTSSCTSLCTSK | |
| SCHEMBL5404869 | 0.66 | CTSS (0.48) | CTSSCTSLCTSKNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1658267-A4 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2007-08-01 | — | — | EP | disclosed |
| EP-1658267-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2006-05-24 | — | — | EP | disclosed |
| WO-2005034848-A2 | INHIBITORS OF CATHEPSIN S | IRM LLC (BM) | 2005-04-21 | — | — | WO | disclosed |