Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 1/20 | 0.46 |
| ▸ | GRM5 | P41594 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PIP4K2C | Q8TBX8 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11079561 | 0.86 | BCAT2 (0.46) | PDK2GRM5KMT2AABCG2HPGD | |
| SCHEMBL2647877 | 0.76 | PDK2 (0.50) | PDK2GRM5KMT2ASMN1; SMN2LMNA | |
| SCHEMBL20073445 | 0.74 | TYK2 (0.46) | PDK2HTTMAPK8MAPK10 | |
| SCHEMBL978600 | 0.72 | KDM4C (0.50) | PDK2KMT2AKDM4CSMN1; SMN2LMNA | |
| SCHEMBL17449218 | 0.72 | KDM4C (0.57) | GRM5KMT2AKDM4CSMN1; SMN2LMNA | |
| SCHEMBL31336603 | 0.71 | ALDH1A1 (0.45) | KMT2ASMN1; SMN2TP53 | |
| SCHEMBL31336940 | 0.71 | CSNK2A1 (0.44) | KMT2ASMN1; SMN2TP53RAB9A | |
| SCHEMBL19207092 | 0.71 | CSNK2A1 (0.44) | KMT2ASMN1; SMN2TP53RAB9A | |
| SCHEMBL13846219 | 0.70 | NPSR1 (0.58) | PDK2GRM5KMT2ASMN1; SMN2LMNA | |
| SCHEMBL16846476 | 0.70 | KDM4C (0.48) | GRM5KMT2AKDM4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794157-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVES | H.Lundbeck A/S (DK) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006032273-A1 | 2-ACYLAMINOTHIAZOLE DERIVATIVES | H. LUNDBECK A/S (DK) | 2006-03-30 | — | — | WO | disclosed |