SCHEMBL5505341

SCHEMBL5505341

CN1CCC(N2c3ccccc3Sc3cc(-c4nnn[nH]4)cc(O)c32)CC1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2D6 P10635 3/20 0.34
CYP1A2 P05177 2/20 0.34
KDM1A O60341 5/20 0.34
BCHE P06276 1/20 0.33
LMNA P02545 2/20 0.32
MAPT P10636 2/20 0.32
MEN1 O00255 1/20 0.32
ALDH1A1 P00352 1/20 0.32
KMT2A Q03164 1/20 0.32
CYP3A4 P08684 2/20 0.32
ABCB11 O95342 2/20 0.31
CHRM2 P08172 2/20 0.31
CHRM4 P08173 2/20 0.31
CHRM5 P08912 2/20 0.31
ADRA2A P08913 2/20 0.31
CHRM1 P11229 2/20 0.31
ADRA2B P18089 2/20 0.31
CHRM3 P20309 2/20 0.31
DRD1 P21728 2/20 0.31
SLC6A2 P23975 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5125807 0.85 CYP2D6 (0.37) CYP2D6CYP1A2KDM1ABCHELMNA
SCHEMBL5226012 0.85
SCHEMBL5221409 0.78 OPRM1 (0.37) CHRM1OPRM1KCNH2OPRK1
SCHEMBL5504478 0.78 CYP2D6 (0.41) CYP2D6CYP1A2KDM1ABCHEMEN1
SCHEMBL5508467 0.75 CHRM2 (0.43) CYP2D6CYP1A2KDM1ABCHELMNA
SCHEMBL5114413 0.73 HTR2C (0.33) KDM1AHTR2AHTR2C
SCHEMBL3183436 0.73 KDM1A (0.34) CYP2D6CYP1A2KDM1AMEN1KMT2A
SCHEMBL9611568 0.71 CYP2D6 (0.55) CYP2D6CYP1A2KDM1ABCHEMEN1
SCHEMBL3173269 0.69 KDM1A (0.30) KDM1A
SCHEMBL5507880 0.69 PIM1 (0.35)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP claimed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO claimed
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP disclosed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO disclosed