Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3167461 | 0.88 | OPRM1 (0.35) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL5226012 | 0.81 | — | — | |
| SCHEMBL5505341 | 0.78 | CYP2D6 (0.34) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL5114019 | 0.75 | HRH3 (0.38) | — | |
| SCHEMBL3167979 | 0.74 | OPRM1 (0.35) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL13394744 | 0.74 | OPRM1 (0.35) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL3183048 | 0.73 | OPRM1 (0.38) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL3987443 | 0.72 | OPRM1 (0.40) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL3176047 | 0.71 | DRD2 (0.38) | OPRM1OPRK1KCNH2CHRM1 | |
| SCHEMBL13394866 | 0.71 | DRD2 (0.38) | OPRM1OPRK1KCNH2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1833826-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-09-19 | — | — | EP | disclosed |
| WO-2006069276-A2 | TRICYCLIC ō-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-06-29 | — | — | WO | disclosed |