SCHEMBL5508467

SCHEMBL5508467

CN1CCC(N2c3ccccc3Sc3cc(C#N)cc(O)c32)CC1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 2/20 0.43
ADRA2A P08913 2/20 0.43
CHRM1 P11229 2/20 0.43
DRD1 P21728 2/20 0.43
PTGS1 P23219 2/20 0.43
SLC6A2 P23975 2/20 0.43
SLC6A4 P31645 2/20 0.43
ADRA1A P35348 2/20 0.43
OPRM1 P35372 2/20 0.43
DRD3 P35462 2/20 0.43
SLC6A3 Q01959 2/20 0.43
KCNH2 Q12809 2/20 0.43
LMNA P02545 1/20 0.43
PGR P06401 1/20 0.43
HTR1A P08908 1/20 0.43
TBXA2R P21731 1/20 0.43
ACHE P22303 1/20 0.43
MAPK1 P28482 1/20 0.43
DRD2 P14416 1/20 0.40
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5507708 0.87 LMNA (0.40) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL5504478 0.83 CYP2D6 (0.41) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL5114986 0.83 ADRA2A (0.49) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL5503886 0.81 CHRM1 (0.41) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL9611568 0.77 CYP2D6 (0.55) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL5505341 0.75 CYP2D6 (0.34) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL5506174 0.70 KDM1A (0.35) SLC6A3BCHEKDM1AHTR2AHTR2C
SCHEMBL5119561 0.69 PIM1 (0.48) CHRM2ADRA2ACHRM1DRD1PTGS1
SCHEMBL5504518 0.69 KDM1A (0.40) OPRM1ACHECYP1A2CYP2D6MAPT
SCHEMBL5119926 0.69 SLC6A2 (0.46) CHRM2ADRA2ACHRM1DRD1PTGS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP claimed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO claimed
EP-1846400-A2 TRICYCLIC DELTA-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2007-10-24 EP disclosed
WO-2006074388-A2 TRICYCLIC δ-OPIOID MODULATORS JANSSEN PHARMACEUTICA N.V. (BE) 2006-07-13 WO disclosed