Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 4/20 | 0.41 |
| ▸ | MGAM | O43451 | 3/20 | 0.41 |
| ▸ | SI | P14410 | 3/20 | 0.41 |
| ▸ | MGAM2 | Q2M2H8 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | STAT1 | P42224 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3075528 | 0.89 | XDH (0.57) | XDHGAAMGAMSIMGAM2 | |
| SCHEMBL3072972 | 0.84 | PDPK1 (0.53) | XDHGAAMGAMSIMGAM2 | |
| SCHEMBL1316525 | 0.76 | TDP1 (0.40) | MAPTALDH1A1TDP1KDM4EPDPK1 | |
| SCHEMBL22531043 | 0.70 | HSPB1 (0.60) | XDHGAAMGAMSIMGAM2 | |
| SCHEMBL23146389 | 0.70 | CDC7 (0.45) | MAPTALDH1A1POLBTDP1KDM4E | |
| SCHEMBL20641472 | 0.69 | XDH (0.68) | XDHGAAMGAMSIMGAM2 | |
| SCHEMBL1314645 | 0.69 | PTPN11 (0.43) | LMNAMAPTNPC1ALDH1A1RAB9A | |
| SCHEMBL29065959 | 0.69 | XDH (0.48) | XDHMAPTALDH1A1TDP1KDM4E | |
| SCHEMBL850770 | 0.69 | SMN1; SMN2 (0.51) | GAAMGAMSIMGAM2LMNA | |
| SCHEMBL16032766 | 0.69 | HDAC1 (0.48) | GAALMNAMAPTNPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846383-A2 | RIGIDIFIED COMPOUNDS FOR MODULATING HEPARANASE ACTIVITY | Insight Biopharmaceuticals Ltd. (IL) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006072953-A2 | RIGIDIFIED COMPOUNDS FOR MODULATING HEPARANASE ACTIVITY | INSIGHT BIOPHARMACEUTICALS LTD. (IL) | 2006-07-13 | — | — | WO | disclosed |