Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 12/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.31 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550499 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL549589 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL549590 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL2699043 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL14405384 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL2699046 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL550504 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| SCHEMBL4570200 | 1.00 | HSD11B1 (0.40) | HSD11B1HRH3ADORA2A | |
| Hydrochloric Acid SCHEMBL549548 | 0.99 | HSD11B1 (0.39) | HSD11B1HRH3ADORA2A | |
| Hydrochloric Acid SCHEMBL549375 | 0.99 | HSD11B1 (0.39) | HSD11B1HRH3ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 49 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11247992-B2 | Cyclopropylamines as LSD1 inhibitors | INCYTE CORPORATION (US) | 2022-02-15 | — | — | US | disclosed |
| US-20210032244-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION | 2021-02-04 | — | — | US | disclosed |
| CN-111454188-A | Cyclopropylamines as L SD1inhibitors | 因赛特公司 | 2020-07-28 | — | — | CN | disclosed |
| CN-106164066-B | Cyclopropylamines as LSD1inhibitors | 因赛特公司 | 2020-01-17 | — | — | CN | disclosed |
| US-10174030-B2 | Cyclopropylamines as LSD1 inhibitors | INCYTE CORPORATION (US) | 2019-01-08 | — | — | US | disclosed |
| US-9873698-B2 | Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE HOLDINGS CORPORATION (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873698-B2 | Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE HOLDINGS CORPORATION (US) | 2018-01-23 | — | — | US | disclosed |
| US-9873698-B2 | Spirocycles as inhibitors of 11-beta hydroxyl steroid dehydrogenase type 1 | INCYTE HOLDINGS CORPORATION (US) | 2018-01-23 | — | — | US | disclosed |
| US-20170342070-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | INCYTE CORPORATION | 2017-11-30 | — | — | US | disclosed |
| US-9670210-B2 | Cyclopropylamines as LSD1 inhibitors | INCYTE CORPORATION (US) | 2017-06-06 | — | — | US | disclosed |
| EP-2173750-B1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORP (US) | 2012-08-01 | — | — | EP | disclosed |
| US-20120122858-A1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2012-05-17 | — | — | US | disclosed |
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | disclosed |
| EP-2173750-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | Incyte Corporation (US) | 2010-04-14 | — | — | EP | disclosed |
| US-20090291946-A1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | INCYTE CORPORATION (US) | 2009-11-26 | — | — | US | disclosed |
| US-20080318991-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080318991-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| US-20080318991-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2008-12-25 | — | — | US | disclosed |
| WO-2008157752-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
| WO-2008157752-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | INCYTE CORPORATION (US) | 2008-12-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291946-A1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885HRH3 1926/4885ADORA2A 2528/4885 |
| US-20170342070-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | KDM1B, KDM1A, KDM2A | HSD11B1 1922/4885HRH3 473/4885ADORA2A 1863/4885 |
| US-11247992-B2 | Cyclopropylamines as LSD1 inhibitors | KDM1B, KDM1A, KDM2A | HSD11B1 1922/4885HRH3 473/4885ADORA2A 1863/4885 |
| US-20210032244-A1 | CYCLOPROPYLAMINES AS LSD1 INHIBITORS | KDM1B, KDM1A, KDM2A | HSD11B1 1922/4885HRH3 473/4885ADORA2A 1863/4885 |
| US-20080318991-A1 | SPIROCYCLES AS INHIBITORS OF 11-BETA HYDROXYL STEROID DEHYDROGENASE TYPE 1 | HSD11B1, HSD17B1, HSD3B1 | HSD11B1 1/4885HRH3 4034/4885ADORA2A 4204/4885 |
| US-10174030-B2 | Cyclopropylamines as LSD1 inhibitors | KDM1B, KDM1A, KDM2A | HSD11B1 1922/4885HRH3 473/4885ADORA2A 1863/4885 |
| US-20120122858-A1 | LACTAM COMPOUNDS AND THEIR USE AS PHARMACEUTICALS | HSD11B1, HSD11B2, HSD17B1 | HSD11B1 1/4885HRH3 1926/4885ADORA2A 2528/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.