Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 5/20 | 0.36 |
| ▸ | GRIA1 | P42261 | 3/20 | 0.36 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.36 |
| ▸ | GRIA3 | P42263 | 3/20 | 0.36 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.36 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PER2 | O15055 | 2/20 | 0.33 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.33 |
| ▸ | HTR7 | P34969 | 2/20 | 0.33 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL550559 | 1.00 | HSD11B1 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL550832 | 1.00 | HSD11B1 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL550833 | 1.00 | HSD11B1 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2700964 | 1.00 | HSD11B1 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2700965 | 1.00 | HSD11B1 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL4570193 | 0.92 | ADAMTS5 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL17082185 | 0.92 | ADAMTS5 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL17082186 | 0.92 | ADAMTS5 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL2702614 | 0.92 | ADAMTS5 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL551000 | 0.92 | ADAMTS5 (0.36) | HSD11B1GRIA1GRIA2GRIA3GRIA4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8110581-B2 | Lactam compounds and their use as pharmaceuticals | INCYTE CORPORATION (US) | 2012-02-07 | — | — | US | claimed |