Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.46 |
| ▸ | DRD4 | P21917 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506807 | 0.91 | DRD4 (0.44) | DRD2DRD4GSK3BACHEKDM4E | |
| SCHEMBL5507199 | 0.90 | DRD2 (0.43) | DRD2DRD4ACHEKDM4EMEN1 | |
| SCHEMBL5121453 | 0.87 | DRD2 (0.49) | DRD2DRD4GSK3BACHEMAPT | |
| SCHEMBL5512732 | 0.84 | DRD4 (0.35) | DRD2DRD4GSK3BACHEKDM4E | |
| SCHEMBL5508780 | 0.84 | L3MBTL1 (0.38) | DRD4KDM4EMAPK1MAPT | |
| SCHEMBL5506511 | 0.83 | DRD2 (0.46) | DRD2DRD4GSK3BACHEMAPT | |
| SCHEMBL5507937 | 0.82 | PIM1 (0.37) | KDM4E | |
| SCHEMBL5503914 | 0.81 | DRD2 (0.35) | DRD2DRD4ACHEKDM4EMEN1 | |
| SCHEMBL5509159 | 0.81 | DRD4 (0.43) | DRD2DRD4ACHE | |
| SCHEMBL5121438 | 0.77 | DRD4 (0.47) | DRD2DRD4GSK3BACHEMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |