Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.38 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.37 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 2/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.35 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5502548 | 0.91 | L3MBTL1 (0.40) | L3MBTL1SRPK1OXTRKDM4ESMN1; SMN2 | |
| SCHEMBL5506807 | 0.89 | DRD4 (0.44) | KDM4ESMN1; SMN2PIK3CAMTORDRD4 | |
| SCHEMBL5112888 | 0.87 | CYP11B1 (0.40) | L3MBTL1SRPK1KDM4ESMN1; SMN2PARP1 | |
| SCHEMBL5512732 | 0.85 | DRD4 (0.35) | OXTRKDM4ESMN1; SMN2PIK3CAMTOR | |
| SCHEMBL5505604 | 0.84 | DRD2 (0.46) | KDM4EDRD4MAPTMAPK1 | |
| SCHEMBL5507937 | 0.81 | PIM1 (0.37) | L3MBTL1KDM4ENPC1RAB9AALDH1A1 | |
| SCHEMBL5509159 | 0.79 | DRD4 (0.43) | PIK3CAMTORDRD4TSHR | |
| SCHEMBL5112952 | 0.77 | L3MBTL1 (0.41) | L3MBTL1SRPK1OXTRKDM4ESMN1; SMN2 | |
| SCHEMBL5508370 | 0.75 | PARP2 (0.35) | SRPK1OXTRKDM4EPARP1PIK3CA | |
| SCHEMBL5121438 | 0.75 | DRD4 (0.47) | SMN1; SMN2PIK3CAMTORDRD4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | claimed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | claimed |
| EP-1846400-A2 | TRICYCLIC DELTA-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2007-10-24 | — | — | EP | disclosed |
| WO-2006074388-A2 | TRICYCLIC δ-OPIOID MODULATORS | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-07-13 | — | — | WO | disclosed |