Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 3/20 | 0.39 |
| ▸ | MTOR | P42345 | 9/20 | 0.36 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.35 |
| ▸ | FKBP1B | P68106 | 1/20 | 0.35 |
| ▸ | PRKDC | P78527 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | INPPL1 | O15357 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
| ▸ | FEN1 | P39748 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506470 | 0.92 | NPY5R (0.40) | NPY5RCD38PIK3CACNR2 | |
| SCHEMBL5509832 | 0.89 | NPY5R (0.41) | NPY5RMTORCD38 | |
| Hydrochloric Acid SCHEMBL5506013 | 0.88 | NPY5R (0.40) | NPY5RMTORCD38 | |
| SCHEMBL5500238 | 0.86 | DPP4 (0.41) | NPY5RMTORATMPIK3CDPIK3CA | |
| SCHEMBL5506141 | 0.86 | CD38 (0.35) | NPY5RCD38DPP4DPP8DPP9 | |
| SCHEMBL5499996 | 0.85 | CNR1 (0.38) | — | |
| SCHEMBL5504552 | 0.85 | NPY5R (0.34) | NPY5RCD38DPP4DPP8DPP9 | |
| SCHEMBL5506180 | 0.85 | AAK1 (0.34) | NPY5RCD38DPP4DPP8DPP9 | |
| SCHEMBL5504232 | 0.84 | CTSS (0.36) | NPY5RCNR2DPP4DPP8DPP9 | |
| Hydrochloric Acid SCHEMBL5504549 | 0.84 | CNR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |