Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 2/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 4/20 | 0.32 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.32 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.32 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.32 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.31 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499996 | 0.90 | CNR1 (0.38) | CCR5JAK2 | |
| SCHEMBL5506180 | 0.89 | AAK1 (0.34) | CD38NPY5RHRH3CCR5CTSS | |
| Hydrochloric Acid SCHEMBL5504549 | 0.89 | CNR1 (0.38) | CCR5JAK2 | |
| SCHEMBL5506470 | 0.88 | NPY5R (0.40) | CD38NPY5RP2RX7PDCD1LG2CD274 | |
| Hydrochloric Acid SCHEMBL5499646 | 0.88 | AAK1 (0.33) | CD38NPY5RHRH3CCR5CTSS | |
| SCHEMBL5504232 | 0.87 | CTSS (0.36) | NPY5RCTSSP2RX7PDCD1LG2CD274 | |
| SCHEMBL5500821 | 0.87 | CNR1 (0.38) | NPY5RCCR5DPP4DPP8DPP9 | |
| SCHEMBL5503995 | 0.86 | CYP11B2 (0.40) | PDCD1LG2CD274 | |
| SCHEMBL5499827 | 0.86 | P2RX7 (0.34) | NPY5RCTSSP2RX7DPP4DPP8 | |
| SCHEMBL5509832 | 0.86 | NPY5R (0.41) | CD38NPY5RP2RX7PDCD1LG2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |