Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPY5R | Q15761 | 4/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | CD38 | P28907 | 1/20 | 0.34 |
| ▸ | ERN1 | O75460 | 1/20 | 0.33 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.33 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 2/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | MELK | Q14680 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509832 | 0.92 | NPY5R (0.41) | NPY5RCD38PDCD1LG2CD274P2RX7 | |
| SCHEMBL5505896 | 0.92 | NPY5R (0.39) | NPY5RPIK3CACD38CNR2 | |
| Hydrochloric Acid SCHEMBL5506013 | 0.91 | NPY5R (0.40) | NPY5RCD38PDCD1LG2CD274P2RX7 | |
| SCHEMBL5504552 | 0.89 | NPY5R (0.34) | NPY5RCD38PDCD1LG2CD274P2RX7 | |
| SCHEMBL5500238 | 0.89 | DPP4 (0.41) | NPY5RPIK3CAPDCD1LG2CD274LTA4H | |
| SCHEMBL5506141 | 0.88 | CD38 (0.35) | NPY5RCD38PDCD1LG2CD274P2RX7 | |
| SCHEMBL5499996 | 0.88 | CNR1 (0.38) | — | |
| SCHEMBL5506180 | 0.87 | AAK1 (0.34) | NPY5RCD38PDCD1LG2CD274P2RX7 | |
| SCHEMBL5504232 | 0.87 | CTSS (0.36) | NPY5RPDCD1LG2CD274P2RX7CNR2 | |
| Hydrochloric Acid SCHEMBL5504549 | 0.87 | CNR1 (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1807072-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2007-07-18 | — | — | EP | claimed |
| WO-2006049952-A1 | CYCLOALKYL LACTAM DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1 | ELI LILLY AND COMPANY (US) | 2006-05-11 | — | — | WO | claimed |