Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PKM | P14618 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | SREBF2 | Q12772 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.48 |
| ▸ | CDC25A | P30304 | 1/20 | 0.46 |
| ▸ | CDC25B | P30305 | 1/20 | 0.46 |
| ▸ | CDC25C | P30307 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4272284 | 0.85 | KDM4E (0.67) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4264751 | 0.79 | PTPN1 (0.47) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL14531237 | 0.77 | CDC25A (0.69) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4275471 | 0.76 | CDC25A (0.47) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4274585 | 0.76 | PPARA (0.48) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL4273584 | 0.75 | KDM4E (0.56) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL11212983 | 0.73 | SREBF2 (0.82) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL11215130 | 0.73 | SREBF2 (0.82) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL11213828 | 0.73 | SREBF2 (0.82) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 | |
| SCHEMBL17336676 | 0.73 | RAB9A (0.66) | KDM4EKMT2AMEN1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794138-A2 | THIAZOLO-NAPHTHYL ACIDS AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Wyeth (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006023866-A2 | THIAZOLO-NAPHTHYL ACIDS AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |