Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.47 |
| ▸ | PPARD | Q03181 | 1/20 | 0.47 |
| ▸ | PPARA | Q07869 | 1/20 | 0.47 |
| ▸ | CDC25A | P30304 | 1/20 | 0.47 |
| ▸ | CDC25B | P30305 | 1/20 | 0.47 |
| ▸ | CDC25C | P30307 | 1/20 | 0.47 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4273584 | 0.85 | KDM4E (0.56) | PTPN1CDC25ACDC25BCDC25CDUSP3 | |
| SCHEMBL4275471 | 0.83 | CDC25A (0.47) | CDC25ACDC25BCDC25CDUSP3SMN1; SMN2 | |
| SCHEMBL4268816 | 0.82 | SMPD1 (0.46) | CDC25ACDC25BCDC25CDUSP3SMN1; SMN2 | |
| SCHEMBL4274585 | 0.82 | PPARA (0.48) | PTPN1PPARASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4274615 | 0.79 | SMN1; SMN2 (0.43) | PTPN1PPARACDC25ACDC25BCDC25C | |
| SCHEMBL4272284 | 0.79 | KDM4E (0.67) | CDC25ACDC25BCDC25CDUSP3SMN1; SMN2 | |
| SCHEMBL5506151 | 0.79 | KDM4E (0.52) | CDC25ACDC25BCDC25CDUSP3SMN1; SMN2 | |
| SCHEMBL4274765 | 0.79 | CDC25A (0.42) | CDC25ACDC25BCDC25CDUSP3SMN1; SMN2 | |
| SCHEMBL1999056 | 0.78 | PTGDR2 (0.65) | PPARDPPARASMN1; SMN2MAPTKDM4E | |
| SCHEMBL3709946 | 0.73 | PRNP (0.71) | SMN1; SMN2ALDH1A1MAPTKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090326021-A1 | THIAZOLO NAPHTHYL ACIDS | WYETH (US) | 2009-12-31 | — | — | US | claimed |
| US-7605172-B2 | Thiazolo-naphthyl acids | WYETH (US) | 2009-10-20 | — | — | US | claimed |
| EP-1794138-A2 | THIAZOLO-NAPHTHYL ACIDS AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Wyeth (US) | 2007-06-13 | — | — | EP | claimed |
| US-20060052420-A1 | Plasminogen activator inhibitor-1 (PAI-1) modulators; 3-phenyl-2-{[6-(2-phenyl-1,3-thiazol-4-yl)-2-naphthyl]oxy}propanoic acid; thrombosis; cardiovascular disease | WYETH (US) | 2006-03-09 | — | — | US | claimed |
| WO-2006023866-A2 | THIAZOLO-NAPHTHYL ACIDS AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | WYETH (US) | 2006-03-02 | — | — | WO | claimed |
| US-20090326021-A1 | THIAZOLO NAPHTHYL ACIDS | WYETH (US) | 2009-12-31 | — | — | US | disclosed |
| US-7605172-B2 | Thiazolo-naphthyl acids | WYETH (US) | 2009-10-20 | — | — | US | disclosed |
| EP-1794138-A2 | THIAZOLO-NAPHTHYL ACIDS AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | Wyeth (US) | 2007-06-13 | — | — | EP | disclosed |
| US-20060052420-A1 | Plasminogen activator inhibitor-1 (PAI-1) modulators; 3-phenyl-2-{[6-(2-phenyl-1,3-thiazol-4-yl)-2-naphthyl]oxy}propanoic acid; thrombosis; cardiovascular disease | WYETH (US) | 2006-03-09 | — | — | US | disclosed |
| WO-2006023866-A2 | THIAZOLO-NAPHTHYL ACIDS AS INHIBITORS OF PLASMINOGEN ACTIVATOR INHIBITOR-1 | WYETH (US) | 2006-03-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090326021-A1 | THIAZOLO NAPHTHYL ACIDS | SERPINE1, SERPINC1, SERPINB1 | PTPN1 1748/4885PPARD 514/4885PPARA 310/4885 |
| US-20060052420-A1 | Plasminogen activator inhibitor-1 (PAI-1) modulators; 3-phenyl-2-{[6-(2-phenyl-1,3-thiazol-4-yl)-2-naphthyl]oxy}propanoic acid; thrombosis; cardiovascular disease | SERPINE1, PLAT, SERPINC1 | PTPN1 519/4885PPARD 205/4885PPARA 107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.