Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | MMP3 | P08254 | 9/20 | 0.46 |
| ▸ | MMP9 | P14780 | 8/20 | 0.46 |
| ▸ | MMP1 | P03956 | 8/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 6/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.43 |
| ▸ | MMP7 | P09237 | 2/20 | 0.43 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MMP13 | P45452 | 2/20 | 0.41 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1039792 | 1.00 | LMNA (0.51) | LMNAMAPTUSP2ALDH1A1GAA | |
| SCHEMBL1040056 | 0.88 | MMP1 (0.41) | LMNAMAPTUSP2ALDH1A1GAA | |
| SCHEMBL1038075 | 0.88 | ESR1 (0.41) | LMNAMAPTUSP2ALDH1A1GAA | |
| SCHEMBL1038263 | 0.87 | LMNA (0.40) | LMNAMAPTUSP2ALDH1A1GAA | |
| SCHEMBL13435377 | 0.87 | NPSR1 (0.51) | LMNAMAPTALDH1A1GAATSHR | |
| SCHEMBL1035128 | 0.87 | TSHR (0.48) | LMNAUSP2ALDH1A1GAATSHR | |
| SCHEMBL2919379 | 0.85 | LMNA (0.45) | LMNAMAPTUSP2ALDH1A1GAA | |
| SCHEMBL8211350 | 0.81 | MMP3 (0.57) | ALDH1A1MMP3MMP9MMP1ADAM17 | |
| SCHEMBL9380136 | 0.76 | MCOLN3 (0.50) | LMNAALDH1A1GAANPSR1KMT2A | |
| SCHEMBL9211270 | 0.76 | MCOLN3 (0.50) | LMNAALDH1A1GAANPSR1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863803-A2 | SUBSTITUTED PIPERIDINES | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103277-A2 | 2 , 4 , 5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |