Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | JAK2 | O60674 | 1/20 | 0.50 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.50 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.50 |
| ▸ | PAK4 | O96013 | 1/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.50 |
| ▸ | LCK | P06239 | 1/20 | 0.50 |
| ▸ | FYN | P06241 | 1/20 | 0.50 |
| ▸ | CSF1R | P07333 | 1/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.50 |
| ▸ | MET | P08581 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | PRKACA | P17612 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505355 | 0.80 | CYP19A1 (0.43) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL5503471 | 0.79 | CHEK1 (0.36) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL28070866 | 0.74 | ACVR1 (0.45) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL26630176 | 0.71 | GSK3B (0.52) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL31469987 | 0.70 | CHEK1 (0.47) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL8147718 | 0.67 | PDE3B (0.41) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL23662305 | 0.65 | BRD4 (0.55) | CDK9 | |
| SCHEMBL10129667 | 0.63 | PDE3B (0.50) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL12992155 | 0.63 | MAPT (0.51) | CHEK1AURKADAPK3JAK2PRKD3 | |
| SCHEMBL10129678 | 0.63 | PDE3B (0.50) | CHEK1AURKADAPK3JAK2PRKD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781642-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006016221-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |