Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 7/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | PAK4 | O96013 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | LCK | P06239 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506950 | 0.80 | CHEK1 (0.50) | CYP19A1ALDH1A1ATAD2CHEK1AURKA | |
| SCHEMBL20548712 | 0.75 | CYP19A1 (0.39) | CYP19A1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5505345 | 0.74 | CYP19A1 (0.36) | CYP19A1CNR2CNR1 | |
| SCHEMBL20616486 | 0.74 | CYP19A1 (0.38) | CYP19A1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL20335475 | 0.74 | CYP19A1 (0.50) | CYP19A1ALDH1A1CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL5503471 | 0.73 | CHEK1 (0.36) | ALDH1A1ATAD2CHEK1AURKADAPK3 | |
| SCHEMBL5501204 | 0.70 | CHEK1 (0.33) | ATAD2CHEK1AURKADAPK3JAK2 | |
| SCHEMBL28070866 | 0.69 | ACVR1 (0.45) | CYP19A1ALDH1A1CYP1A2ATAD2CHEK1 | |
| SCHEMBL3648722 | 0.68 | PARK7 (0.50) | ALDH1A1MAPTCA12CA1CA2 | |
| SCHEMBL5116351 | 0.67 | ATAD2 (0.57) | CYP19A1ALDH1A1ATAD2ACVR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781642-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | Pharmacia & Upjohn Company LLC (US) | 2007-05-09 | — | — | EP | disclosed |
| WO-2006016221-A1 | OXAZOLIDINONES CONTAINING OXINDOLES AS ANTIBACTERIAL AGENTS | PHARMACIA & UPJOHN COMPANY LLC (US) | 2006-02-16 | — | — | WO | disclosed |