Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.44 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506989 | 0.76 | ROCK2 (0.46) | KDM4EMTNR1AMTNR1BROCK2LMNA | |
| SCHEMBL3372837 | 0.74 | ROCK2 (0.50) | KDM4EMTNR1AMTNR1BROCK2LMNA | |
| SCHEMBL3372840 | 0.74 | ROCK2 (0.50) | KDM4EMTNR1AMTNR1BROCK2LMNA | |
| SCHEMBL3452803 | 0.74 | ROCK2 (0.50) | KDM4EMTNR1AMTNR1BROCK2LMNA | |
| SCHEMBL3452807 | 0.74 | ROCK2 (0.50) | KDM4EMTNR1AMTNR1BROCK2LMNA | |
| SCHEMBL5503275 | 0.70 | MTNR1B (0.41) | MTNR1AMTNR1BKCNH2 | |
| SCHEMBL3376049 | 0.69 | MTNR1A (0.46) | MTNR1AMTNR1BROCK2KCNH2 | |
| SCHEMBL3410554 | 0.69 | MTNR1A (0.46) | MTNR1AMTNR1BROCK2KCNH2 | |
| SCHEMBL3410549 | 0.69 | MTNR1A (0.46) | MTNR1AMTNR1BROCK2KCNH2 | |
| SCHEMBL3376051 | 0.69 | MTNR1A (0.46) | MTNR1AMTNR1BROCK2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1799676-A2 | NEW BICYCLIC ANTIBIOTICS | Actelion Pharmaceuticals Ltd. (CH) | 2007-06-27 | — | — | EP | disclosed |
| WO-2006032466-A2 | NEW BICYCLIC ANTIBIOTICS | ACTELION PHARMACEUTICALS LTD (CH) | 2006-03-30 | — | — | WO | disclosed |