Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.46 |
| ▸ | MAOB | P27338 | 2/20 | 0.45 |
| ▸ | LNPEP | Q9UIQ6 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.43 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.43 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.43 |
| ▸ | GUSB | P08236 | 1/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2319276 | 0.88 | LMNA (0.58) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL4213552 | 0.83 | LMNA (0.58) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL391547 | 0.82 | MEN1 (0.71) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL183994 | 0.82 | LMNA (0.70) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL3132629 | 0.81 | LMNA (0.62) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL2859259 | 0.80 | SLC7A5 (0.60) | HPGDMEN1KMT2AMRGPRX4SMN1; SMN2 | |
| SCHEMBL5505769 | 0.80 | CA1 (0.53) | LMNAHPGDMRGPRX4SLC7A5 | |
| SCHEMBL2656262 | 0.80 | LMNA (0.56) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL731998 | 0.79 | LMNA (0.59) | LMNAHPGDMEN1KMT2AMRGPRX4 | |
| SCHEMBL1427184 | 0.79 | GCK (0.61) | LMNAHPGDMEN1KMT2AMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828147-A1 | QUINOXALINES AS B-RAF INHIBITORS | AstraZeneca AB (SE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006040568-A1 | QUINOXALINES AS B RAF INHIBITORS | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |