Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 6/20 | 0.53 |
| ▸ | CA2 | P00918 | 6/20 | 0.53 |
| ▸ | CA12 | O43570 | 5/20 | 0.53 |
| ▸ | CA7 | P43166 | 5/20 | 0.53 |
| ▸ | CA9 | Q16790 | 5/20 | 0.53 |
| ▸ | CA14 | Q9ULX7 | 5/20 | 0.53 |
| ▸ | SLC7A5 | Q01650 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5247377 | 0.84 | SLC7A5 (0.43) | CA1CA2CA12CA7CA9 | |
| SCHEMBL5506080 | 0.84 | SLC7A5 (0.46) | CA1CA2CA12CA7CA9 | |
| SCHEMBL2319081 | 0.83 | CA12 (0.61) | CA1CA2CA12CA7CA9 | |
| SCHEMBL2859259 | 0.80 | SLC7A5 (0.60) | SLC7A5KDM4EHPGDLOXL2MRGPRX4 | |
| SCHEMBL5507004 | 0.80 | LMNA (0.53) | SLC7A5LMNAHPGDMRGPRX4 | |
| SCHEMBL5264624 | 0.79 | SLC7A5 (0.39) | CA1CA2CA12CA7CA9 | |
| SCHEMBL90400 | 0.76 | CA1 (0.70) | CA1CA2CA12CA7CA9 | |
| SCHEMBL710342 | 0.75 | CA12 (0.68) | CA1CA2CA12CA7CA9 | |
| SCHEMBL11690126 | 0.73 | CA12 (0.51) | CA1CA2CA12CA7CA9 | |
| SCHEMBL14102418 | 0.73 | SLC7A5 (0.54) | CA1CA2CA12CA7CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828147-A1 | QUINOXALINES AS B-RAF INHIBITORS | AstraZeneca AB (SE) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006040568-A1 | QUINOXALINES AS B RAF INHIBITORS | ASTRAZENECA AB (SE) | 2006-04-20 | — | — | WO | disclosed |