Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.47 |
| ▸ | CA9 | Q16790 | 3/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.42 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.42 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.42 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.42 |
| ▸ | UGT1A7 | Q9HAW7 | 1/20 | 0.42 |
| ▸ | SLC22A11 | Q9NSA0 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505271 | 0.95 | CA12 (0.48) | CA12CA9TSHRALDH1A1HCRTR2 | |
| SCHEMBL9307793 | 0.95 | ALDH1A1 (0.47) | CA12CA9TSHRALDH1A1TP53 | |
| SCHEMBL3693999 | 0.92 | TSHR (0.49) | CA12CA9TSHRALDH1A1HCRTR2 | |
| SCHEMBL2583710 | 0.86 | TSHR (0.57) | TSHRALDH1A1TP53HCRTR2RAB9A | |
| SCHEMBL28278188 | 0.81 | TDP1 (0.41) | ALDH1A1TP53HCRTR2TDP1MAPK1 | |
| SCHEMBL6843428 | 0.81 | HDAC3 (0.47) | CA9ALDH1A1TP53HCRTR2CA2 | |
| SCHEMBL9683547 | 0.80 | SMN1; SMN2 (0.46) | CA12CA9ALDH1A1TP53HCRTR2 | |
| SCHEMBL9308951 | 0.79 | TSHR (0.50) | CA12CA9TSHRALDH1A1SMN1; SMN2 | |
| SCHEMBL8527676 | 0.79 | KMT2A (0.47) | CA12CA9TSHRALDH1A1TP53 | |
| SCHEMBL6062172 | 0.78 | TSHR (0.49) | CA12CA9TSHRALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1549306-A4 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH CORP (US) | 2007-06-06 | — | — | EP | claimed |
| EP-1549306-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | Wyeth (US) | 2005-07-06 | — | — | EP | claimed |
| WO-2003103660-A1 | SUBSTITUTED PHENYLSULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION | WYETH (US) | 2003-12-18 | — | — | WO | claimed |