Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 2/20 | 0.36 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.33 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | EDNRB | P24530 | 2/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5503959 | 0.94 | REN (0.36) | RENTHRBCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL2923548 | 0.91 | TMEM97 (0.35) | RENSIRT2SIRT1THRBALDH1A1 | |
| SCHEMBL4958115 | 0.89 | REN (0.35) | RENTHRBCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL4646776 | 0.88 | REN (0.34) | RENTHRBCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL2916067 | 0.86 | TMEM97 (0.36) | RENTHRBALDH1A1 | |
| SCHEMBL2921502 | 0.86 | TMEM97 (0.36) | RENTHRBALDH1A1 | |
| SCHEMBL3903011 | 0.86 | REN (0.36) | REN | |
| SCHEMBL4145756 | 0.85 | REN (0.38) | RENTHRBCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL2919377 | 0.84 | REN (0.37) | RENSIRT2SIRT1THRBCYP3A4 | |
| SCHEMBL2921899 | 0.84 | TP53 (0.37) | RENTHRBCYP3A4CYP2C19ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863803-A2 | SUBSTITUTED PIPERIDINES | Speedel Experimenta AG (CH) | 2007-12-12 | — | — | EP | disclosed |
| WO-2006103277-A2 | 2 , 4 , 5-SUBSTITUTED PIPERIDINES AS RENIN INHIBITORS | SPEEDEL EXPERIMENTA AG (CH) | 2006-10-05 | — | — | WO | disclosed |