Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTHFD2 | P13995 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | DRD4 | P21917 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2978467 | 0.83 | HDAC1 (0.47) | MTHFD2HDAC1NPC1SIGMAR1HPGD | |
| SCHEMBL5370174 | 0.83 | MTHFD2 (0.73) | MTHFD2NPC1HPGDSMN1; SMN2KDM4E | |
| SCHEMBL15769678 | 0.81 | HDAC1 (0.45) | MTHFD2HDAC1RAB9ADRD4 | |
| SCHEMBL26675952 | 0.77 | MTHFD2 (0.44) | MTHFD2HDAC1NPC1SIGMAR1HPGD | |
| SCHEMBL29736024 | 0.77 | MTHFD2 (0.44) | MTHFD2HDAC1NPC1SIGMAR1HPGD | |
| SCHEMBL10385974 | 0.77 | MEN1 (0.56) | TSHRHTTSMN1; SMN2KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL10387278 | 0.76 | MEN1 (0.55) | TSHRHTTSMN1; SMN2KDM4ETP53 | |
| Hydrochloric Acid SCHEMBL5503498 | 0.75 | MTHFD2 (0.48) | MTHFD2HDAC1NPC1SIGMAR1HPGD | |
| SCHEMBL8033070 | 0.75 | SIGMAR1 (0.50) | HDAC1NPC1SIGMAR1HPGDTSHR | |
| SCHEMBL15016186 | 0.75 | DRD2 (0.46) | HDAC1NPC1HPGDKDM4ERAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1831227-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | Glenmark Pharmaceuticals S.A. (CH) | 2007-09-12 | — | — | EP | disclosed |
| WO-2006064355-A2 | NOVEL HETEROCYCLIC COMPOUNDS USEFUL FOR THE TREATMENT OF INFLAMMATORY AND ALLERGIC DISORDERS | GLENMARK PHARMACEUTICALS S.A. (US) | 2006-06-22 | — | — | WO | disclosed |