Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | NPC1 | O15118 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.64 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.64 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | BCHE | P06276 | 1/20 | 0.64 |
| ▸ | CFTR | P13569 | 1/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | ACHE | P22303 | 1/20 | 0.64 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.64 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31563000 | 1.00 | RAB9A (0.65) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL5506562 | 0.96 | RAB9A (0.65) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL5509709 | 0.88 | ALDH1A1 (0.70) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6923330 | 0.86 | KDM4E (0.58) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6922253 | 0.85 | RAB9A (0.63) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL5511724 | 0.84 | ALDH1A1 (0.69) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL6921520 | 0.83 | L3MBTL1 (0.54) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL5511719 | 0.82 | NPC1 (0.65) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL31563002 | 0.82 | SMN1; SMN2 (0.79) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E | |
| SCHEMBL17221115 | 0.82 | SMN1; SMN2 (0.79) | RAB9ANPC1ALDH1A1L3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1521583-B1 | 7,8,9,10-TETRAHYDRO-6H-AZEPINO, 6,7,8,9-TETRAHYDRO-PYRIDO AND 2,3-DIHYDRO-2H-PYRROLO (2,1-B)-QUINAZOLINONE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-01-10 | — | — | EP | disclosed |
| US-7067519-B2 | 7,8,9,10-tetrahydro-6H-azepino, 6,7,8,9-tetrahydro-pyrido and 2,3-dihydro-2H-pyrrolo[2,1-b]-quinazolinone derivatives | ACTELION PHARMACEUTICALS, LTD. (CH) | 2006-06-27 | — | — | US | disclosed |
| US-20050009852-A1 | 7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates | ACTELION PHARMACEUTICALS, LTD. (CH) | 2005-01-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050009852-A1 | 7 8 9 10-tetrahydro-6h-azepino, 6 7 8 9-tetrahydro-pyrido and 2 3-dihydro-2h-pyrrolo[2 1-b]-quinazolinone derivates | HCRTR2, HCRTR1, NPY1R | RAB9A 549/4885NPC1 1429/4885ALDH1A1 1416/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.