Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 4/20 | 0.46 |
| ▸ | MMP14 | P50281 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ADAMTS4 | O75173 | 5/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5505431 | 0.89 | MMP13 (0.48) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL2155796 | 0.85 | MMP13 (0.50) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL2156329 | 0.83 | MMP13 (0.48) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL2156890 | 0.81 | TP53 (0.48) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL2155260 | 0.80 | THRB (0.40) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL2156038 | 0.79 | MMP13 (0.61) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL2156043 | 0.79 | TP53 (0.49) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL16493547 | 0.77 | AR (0.39) | LMNAPOLBALDH1A1HPGDKDM4E | |
| SCHEMBL16493578 | 0.74 | LMNA (0.48) | MMP13MMP14CYP3A4TP53LMNA | |
| SCHEMBL16493579 | 0.74 | LMNA (0.52) | TP53LMNAPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | claimed |
| EP-1828160-B1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | MERCK SERONO SA (CH) | 2011-12-14 | — | — | EP | disclosed |
| EP-1828160-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF AS MMP INHIBITORS | LABORATOIRES SERONO S.A. (CH) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006067114-A1 | SULFONYL AMINO CYCLIC DERIVATIVES AND USE THEREOF | LABORATOIRES SERONO S.A. (CH) | 2006-06-29 | — | — | WO | disclosed |