Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDGFRA | P16234 | 8/20 | 0.39 |
| ▸ | KIT | P10721 | 3/20 | 0.39 |
| ▸ | KDR | P35968 | 4/20 | 0.39 |
| ▸ | MET | P08581 | 6/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | BTK | Q06187 | 4/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | TEC | P42680 | 1/20 | 0.37 |
| ▸ | TXK | P42681 | 1/20 | 0.37 |
| ▸ | BLK | P51451 | 1/20 | 0.37 |
| ▸ | BMX | P51813 | 1/20 | 0.37 |
| ▸ | JAK3 | P52333 | 1/20 | 0.37 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.37 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5518997 | 0.89 | PDGFRA (0.39) | PDGFRAKITKDRMETEGFR | |
| SCHEMBL5506278 | 0.89 | MET (0.36) | PDGFRAKDRMETDDR2AXL | |
| SCHEMBL5510840 | 0.85 | MET (0.36) | METEGFRBTKERBB2TEC | |
| SCHEMBL5508442 | 0.84 | MEN1 (0.41) | PDGFRAKIT | |
| SCHEMBL5505043 | 0.83 | CLK4 (0.36) | AXL | |
| SCHEMBL5518881 | 0.78 | AAK1 (0.33) | PDGFRAKITKDRMETDDR2 | |
| SCHEMBL5509030 | 0.76 | EGFR (0.38) | METEGFR | |
| SCHEMBL5506720 | 0.75 | MET (0.33) | METEGFRBTKERBB2TEC | |
| SCHEMBL3025813 | 0.75 | EGFR (0.37) | EGFR | |
| SCHEMBL5509074 | 0.75 | FLT3 (0.33) | METAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797085-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029861-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |