Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.34 |
| ▸ | TEC | P42680 | 1/20 | 0.34 |
| ▸ | TXK | P42681 | 1/20 | 0.34 |
| ▸ | BLK | P51451 | 1/20 | 0.34 |
| ▸ | BMX | P51813 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.34 |
| ▸ | CISD1 | Q9NZ45 | 1/20 | 0.32 |
| ▸ | PDPK1 | O15530 | 5/20 | 0.32 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.32 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | RECQL | P46063 | 2/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5506278 | 0.90 | MET (0.36) | METCISD1PDPK1DDR2KDM4E | |
| SCHEMBL5506720 | 0.89 | MET (0.33) | METEGFRERBB2TECTXK | |
| SCHEMBL5508606 | 0.85 | PDGFRA (0.39) | METEGFRERBB2TECTXK | |
| SCHEMBL5513118 | 0.83 | KMT2A (0.47) | MEN1KMT2AKDM4EMAPTRECQL | |
| SCHEMBL5519374 | 0.82 | KDM1A (0.39) | METEGFRMEN1KMT2A | |
| SCHEMBL5509074 | 0.81 | FLT3 (0.33) | METCISD1PDPK1FLT3 | |
| SCHEMBL5518881 | 0.79 | AAK1 (0.33) | METCISD1PDPK1DDR2CSF1R | |
| SCHEMBL5518997 | 0.77 | PDGFRA (0.39) | METEGFRERBB2TECTXK | |
| SCHEMBL5502774 | 0.76 | HTT (0.35) | PDPK1MEN1KMT2AKDM4EMAPT | |
| SCHEMBL3025813 | 0.76 | EGFR (0.37) | EGFRPDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1797085-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. Hoffmann-Roche AG (CH) | 2007-06-20 | — | — | EP | disclosed |
| WO-2006029861-A1 | THIAZOLINONE 4-MONOSUBSTITUTED QUINOLINES | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-23 | — | — | WO | disclosed |