Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.43 |
| ▸ | KDM6B | O15054 | 1/20 | 0.43 |
| ▸ | KDM4A | O75164 | 1/20 | 0.43 |
| ▸ | KDM5C | P41229 | 1/20 | 0.43 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.43 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.43 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | P4HTM | Q9NXG6 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | TDO2 | P48775 | 1/20 | 0.40 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CCR1 | P32246 | 1/20 | 0.38 |
| ▸ | CCR5 | P51681 | 1/20 | 0.38 |
| ▸ | CCR8 | P51685 | 1/20 | 0.38 |
| ▸ | METAP1 | P53582 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1477084 | 0.76 | PRKCI (0.47) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL10819139 | 0.72 | NAPRT (0.50) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL29852117 | 0.72 | TGFBR1 (0.54) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL23294714 | 0.72 | TGFBR1 (0.54) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL949058 | 0.69 | PIN1 (0.49) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL26119478 | 0.69 | PRKCI (0.46) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL8679235 | 0.69 | KDM4E (0.42) | KDM4ELMNAP4HTML3MBTL1TDO2 | |
| Dipyridyl SCHEMBL20448088 | 0.68 | KDM4E (0.67) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL1173966 | 0.68 | KDM4E (0.52) | PIN1KDM4EKDM6BKDM4AKDM5C | |
| SCHEMBL30457761 | 0.68 | PRKCI (0.53) | KDM4ELMNAP4HTML3MBTL1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1753724-A1 | HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2007-02-21 | — | — | EP | disclosed |
| WO-2005123686-A1 | HETEROCYCLIC DERIVATIVES FOR TREATMENT OF HYPERLIPIDEMIA AND RELATED DISEASES | AVANIR PHARMACEUTICALS (US) | 2005-12-29 | — | — | WO | disclosed |