Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | MRGPRX2 | Q96LB1 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23256417 | 0.85 | MAPT (0.46) | MAPTKMT2ARECQLCYP1A2SMN1; SMN2 | |
| SCHEMBL4557331 | 0.84 | MAPT (0.44) | MAPTKMT2ACYP1A2SMN1; SMN2CYP3A4 | |
| Bromide SCHEMBL5138481 | 0.83 | MAPT (0.43) | MAPTKMT2ACYP1A2SMN1; SMN2CYP3A4 | |
| SCHEMBL9667392 | 0.81 | KIF11 (0.44) | MAPTKMT2ACYP1A2CYP3A4ALDH1A1 | |
| SCHEMBL27592432 | 0.77 | TAAR1 (0.41) | MAPTKMT2ACYP1A2SMN1; SMN2CYP3A4 | |
| SCHEMBL20293767 | 0.77 | MAPT (0.47) | MAPTKMT2ACYP1A2CYP3A4HIF1A | |
| SCHEMBL8938100 | 0.76 | MAPT (0.50) | MAPTKMT2ACYP1A2SMN1; SMN2CYP3A4 | |
| SCHEMBL4561507 | 0.76 | CYP2D6 (0.50) | MAPTKMT2ACYP3A4HIF1ACYP2C19 | |
| SCHEMBL17653676 | 0.76 | CYP2D6 (0.43) | MAPTKMT2ACYP1A2SMN1; SMN2CYP3A4 | |
| SCHEMBL17653674 | 0.76 | CYP2D6 (0.43) | MAPTKMT2ACYP1A2SMN1; SMN2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1814866-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | Wyeth a Corporation of the State of Delaware (US) | 2007-08-08 | — | — | EP | disclosed |
| WO-2006058012-A2 | GONADOTROPIN RELEASING HORMONE RECEPTOR ANTAGONISTS | WYETH (US) | 2006-06-01 | — | — | WO | disclosed |