Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR52 | Q9Y2T5 | 7/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 10/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 11/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.40 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17881196 | 0.79 | PIK3CD (0.45) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL5508446 | 0.79 | ATAD2 (0.39) | GPR52PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL924229 | 0.78 | PIK3CB (0.67) | PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL48824 | 0.77 | ALDH1A1 (0.46) | GPR52PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL924892 | 0.70 | MEN1 (0.45) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL17881197 | 0.70 | PIK3CD (0.49) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL17881231 | 0.69 | PIK3CA (0.49) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL31543990 | 0.69 | PIK3CG (0.46) | GPR52PIK3CBPIK3CAPIK3CDPIK3CG | |
| SCHEMBL17881217 | 0.69 | PIK3CD (0.58) | PIK3CBPIK3CAPIK3CDPIK3CGPIK3C3 | |
| SCHEMBL3638579 | 0.68 | ALDH1A1 (0.54) | GPR52 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841763-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | AstraZeneca AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006051270-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS P13K INHIBITORS | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |