Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.39 |
| ▸ | GPR52 | Q9Y2T5 | 13/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | DDO | Q99489 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48824 | 0.82 | ALDH1A1 (0.46) | GPR52ALDH1A1RAB9AL3MBTL1PIK3CD | |
| SCHEMBL5509834 | 0.79 | GPR52 (0.42) | GPR52PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL925427 | 0.75 | PIK3CG (0.56) | ATAD2PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3638579 | 0.73 | ALDH1A1 (0.54) | GPR52ALDH1A1RAB9AL3MBTL1HTT | |
| SCHEMBL6550116 | 0.70 | GPR52 (0.52) | GPR52ALDH1A1KDM4EMEN1LMNA | |
| SCHEMBL31543990 | 0.66 | PIK3CG (0.46) | GPR52PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2835239 | 0.64 | PIK3CG (0.64) | ALDH1A1PIK3CGHTTKDM4EMEN1 | |
| SCHEMBL2091615 | 0.62 | ALDH1A1 (0.50) | ALDH1A1RAB9AL3MBTL1HTTF2 | |
| SCHEMBL2890226 | 0.62 | F2 (0.39) | ALDH1A1RAB9AL3MBTL1HTTF2 | |
| SCHEMBL5960416 | 0.62 | ALDH1A1 (0.47) | ALDH1A1RAB9AL3MBTL1HTTF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841763-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS PI3K INHIBITORS | AstraZeneca AB (SE) | 2007-10-10 | — | — | EP | disclosed |
| WO-2006051270-A1 | 5-HETEROARYL THIAZOLES AND THEIR USE AS P13K INHIBITORS | ASTRAZENECA AB (SE) | 2006-05-18 | — | — | WO | disclosed |