Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.46 |
| ▸ | SOAT1 | P35610 | 1/20 | 0.46 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.43 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.43 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.43 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.43 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.43 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.43 |
| ▸ | PSMA4 | P25789 | 1/20 | 0.43 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.43 |
| ▸ | PSMB9 | P28065 | 1/20 | 0.43 |
| ▸ | PSMA5 | P28066 | 1/20 | 0.43 |
| ▸ | PSMB4 | P28070 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20194447 | 0.84 | CYP3A4 (0.54) | CYP3A4KDM4ETP53MAPTALOX15 | |
| SCHEMBL7959789 | 0.80 | CYP3A4 (0.49) | CYP3A4KDM4ETP53MAPTALOX15 | |
| SCHEMBL18415560 | 0.80 | MAPT (0.51) | CYP3A4KDM4ETP53MAPTALOX15 | |
| SCHEMBL28102499 | 0.79 | GAA (0.69) | TGM2KDM4EMAPTTSHRGAA | |
| SCHEMBL5041890 | 0.79 | TGM2 (0.69) | TGM2CYP3A4TP53MAPTTSHR | |
| SCHEMBL3701198 | 0.79 | KDM4E (0.46) | CYP3A4KDM4ETP53MAPTALOX15 | |
| SCHEMBL7959792 | 0.78 | MAPT (0.50) | CYP3A4KDM4ETP53MAPTALOX15 | |
| SCHEMBL9641181 | 0.77 | CYP3A4 (0.49) | CYP3A4KDM4ETP53MAPTALOX15 | |
| SCHEMBL28835016 | 0.76 | NPSR1 (0.63) | TGM2TP53MAPTGAAALDH1A1 | |
| SCHEMBL14431056 | 0.75 | PSMB11 (0.41) | TGM2CYP3A4PSMB11PSMA7PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1539675-A4 | ARYL AND HETEROARYL PROPENE AMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF | UNIV TEMPLE (US) | 2007-07-11 | — | — | EP | disclosed |
| EP-1539675-A2 | ARYL AND HETEROARYL PROPENE AMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF | Temple University of the Commonwealth System of Higher Education (US) | 2005-06-15 | — | — | EP | disclosed |
| WO-2004037751-A2 | ARYL AND HETEROARYL PROPENE AMIDES, DERIVATIVES THEREOF AND THERAPEUTIC USES THEREOF | TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION (US) | 2004-05-06 | — | — | WO | disclosed |