Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 6/20 | 0.41 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.39 |
| ▸ | FNTA | P49354 | 2/20 | 0.38 |
| ▸ | FNTB | P49356 | 2/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3314536 | 0.91 | CCR2 (0.45) | CCR2TRPV1P2RX7PDE4APDE4B | |
| SCHEMBL3316036 | 0.80 | CCR2 (0.42) | CCR2 | |
| SCHEMBL3316511 | 0.77 | CCR2 (0.45) | CCR2TRPV1SRD5A1SRD5A2 | |
| SCHEMBL3315505 | 0.77 | CCR2 (0.46) | CCR2TRPV1PDE10AOPRL1SRD5A1 | |
| SCHEMBL3313029 | 0.74 | CCR2 (0.46) | CCR2TRPV1KDM1AMAOAMAOB | |
| SCHEMBL3316278 | 0.73 | MAOA (0.49) | CCR2PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL29516137 | 0.70 | CA12 (0.63) | TRPV1P2RX7PDE4APDE4BPDE4C | |
| SCHEMBL27480803 | 0.70 | HDAC1 (0.54) | — | |
| SCHEMBL26956102 | 0.70 | CA12 (0.63) | TRPV1P2RX7PDE4APDE4BPDE4C | |
| SCHEMBL16485928 | 0.69 | SPR (0.43) | CCR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828122-A2 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS | Pfizer Limited (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006064351-A2 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS | PFIZER LIMITED (GB) | 2006-06-22 | — | — | WO | disclosed |