SCHEMBL5510318

SCHEMBL5510318

CNc1cc(F)c(Cc2c(F)cc(NC)cc2F)c(F)c1

nearest known ligand 0.32

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.32
KCNH2 Q12809 1/20 0.31
TAAR1 Q96RJ0 2/20 0.31
RAPGEF4 Q8WZA2 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21736799 0.85
SCHEMBL1637217 0.78 RAPGEF4 (0.46) TSHRKCNH2RAPGEF4
SCHEMBL25908497 0.77
SCHEMBL5518604 0.76 RAPGEF4 (0.35) TSHRKCNH2RAPGEF4
SCHEMBL5516191 0.76 HDAC1 (0.41) TSHRKCNH2RAPGEF4
SCHEMBL19987627 0.74 MEN1 (0.35) TSHRKCNH2TAAR1
SCHEMBL25082732 0.74 KCNH2 (0.34) TSHRKCNH2RAPGEF4
SCHEMBL5517876 0.74 MEP1B (0.37)
SCHEMBL5515615 0.74 HDAC1 (0.40) TSHRKCNH2RAPGEF4
SCHEMBL5515696 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7208559-B2 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2007-04-24 US disclosed
US-20060135712-A1 Ethylened polymer and molded object obtained therefrom MITSUI CHEMICALS, INC. (JP) 2006-06-22 US disclosed