Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD3 | P35462 | 5/20 | 0.38 |
| ▸ | HTR6 | P50406 | 3/20 | 0.38 |
| ▸ | HTR1A | P08908 | 2/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5499969 | 0.92 | HTR1A (0.36) | DRD2DRD3HTR6HTR1ATSHR | |
| SCHEMBL2782811 | 0.81 | DRD2 (0.56) | DRD2DRD3HTR6HTR1ATSHR | |
| SCHEMBL2781544 | 0.79 | TSHR (0.48) | DRD2DRD3HTR6TSHRMAPK1 | |
| SCHEMBL2780978 | 0.73 | DRD2 (0.52) | DRD2DRD3HTR6 | |
| SCHEMBL5501923 | 0.73 | DRD2 (0.39) | DRD2DRD3HTR6HTR1A | |
| SCHEMBL2783198 | 0.71 | HTR1A (0.46) | DRD2DRD3HTR1AALDH1A1NPSR1 | |
| SCHEMBL2783830 | 0.71 | DRD2 (0.45) | DRD2DRD3HTR6TSHRMAPK1 | |
| SCHEMBL2783275 | 0.69 | DRD2 (0.55) | DRD2DRD3HTR6HTR1A | |
| SCHEMBL2783581 | 0.69 | DRD2 (0.61) | DRD2DRD3HTR6HTR1A | |
| SCHEMBL2783014 | 0.69 | DRD2 (0.57) | DRD2DRD3HTR6HTR1AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773772-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2007-04-18 | — | — | EP | disclosed |
| WO-2005121087-A1 | NEW DISUBSTITUTED PHENYLPIPERIDINES/PIPERAZINES AS MODULATORS OF DOPAMINE NEUROTRANSMISSION | A. CARLSSON RESEARCH AB (SE) | 2005-12-22 | — | — | WO | disclosed |