Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5516664 | 0.84 | GAA (0.47) | HRH3GAAALDH1A1POLB | |
| SCHEMBL5514914 | 0.81 | HRH3 (0.40) | LMNAHRH3ALDH1A1HPGDCYP2D6 | |
| SCHEMBL5516041 | 0.81 | SMN1; SMN2 (0.43) | LMNAHSD17B10HRH3GAAALDH1A1 | |
| SCHEMBL7307925 | 0.81 | LMNA (0.59) | LMNAHSD17B10GAAMAPTL3MBTL1 | |
| SCHEMBL16708787 | 0.80 | HRH3 (0.39) | HRH3ALDH1A1POLBCYP2D6KCNH2 | |
| SCHEMBL5513382 | 0.80 | HPGD (0.61) | LMNAHRH3ALDH1A1HPGD | |
| SCHEMBL5517785 | 0.80 | ALDH1A1 (0.42) | LMNAHSD17B10GAAMAPTALDH1A1 | |
| SCHEMBL5520234 | 0.80 | KMT2A (0.42) | LMNAHSD17B10HRH3GAAHPGD | |
| SCHEMBL12308632 | 0.78 | LMNA (0.49) | LMNAHSD17B10HRH3GAAMAPT | |
| SCHEMBL5606073 | 0.78 | LMNA (0.56) | LMNAHSD17B10GAAMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8367666-B2 | 3-carbamoyl-2-pyridone derivatives | SHIONOGI & CO., LTD. (JP) | 2013-02-05 | — | — | US | disclosed |
| US-8178681-B2 | methyl 3-methyl-2-{[2-oxo-1-(2-oxo-ethyl)-1,2,5,6,7,8,9,10-octahydro-cycloocta[b]pyridine-3-carbonyl]-amino}-butyrate; cannabinoid receptor agonist; antiinflammatory agent, immunostimulant, analgesic; atopic dermatitis; excellent in photostability, and have excellent transdermal and oral absorbency | SHIONOGI & CO., LTD. (JP) | 2012-05-15 | — | — | US | disclosed |